Manufacturer: Euro-Pharmacies, Europe
Pharmaceutical name: Pegylated Mechano Growth Factor
Pack: 1 vial (2 mg)
PEG-MGF, or PEGylated Mechano Growth Factor, is an advanced and groundbreaking variant of MGF that significantly outperforms its natural counterpart. MGF is a splice variant of the IGF gene, which boosts the number of stem cells in muscle tissue and promotes the fusion and maturation of muscle fibers, a crucial process for adult muscle growth. Unlike natural MGF, which is produced locally and does not enter the bloodstream, synthetic MGF is water-based and, when injected intramuscularly, makes its way into the bloodstream. However, MGF remains stable in the bloodstream for only a matter of minutes.
PEGylation refers to the process of attaching a Polyethylene glycol (PEG) structure to a larger molecule (in this instance, MGF). This PEG functions as a protective coating, with the aim of enabling MGF to traverse the bloodstream without being degraded.
MGF has localized effects in skeletal muscle and cannot circulate throughout the body without modification. The challenge with synthetic MGF is that, being water-based and administered intramuscularly, it enters the bloodstream and remains stable there for only a few moments. In contrast, biologically produced MGF is synthesized locally and does not penetrate the bloodstream; it is also short-acting, so stability is not a concern. PEGylating MGF enhances its efficacy, making it comparable to locally produced MGF when used intramuscularly. This is achieved by encasing part of the peptide in a polyethylene glycol structure that can bond with a protein molecule. The PEG groups shield the peptide, while still allowing the active sites to remain available for biological interaction. In this scenario, the coating acts as a negatively charged barrier against positively charged substances that could negatively impact the protein.
Neurological studies have demonstrated that the use of PEGylated MGF leads to a longer-lasting and more stable form of the MGF peptide in serum or blood.